Minor Sulfonamides may compete with penicillin for renal tubular secretion, increasing penicillin serum concentrations. These combinations should be used with caution and patients monitored for increased side effects. Minor Ethacrynic acid may compete with penicillin for renal tubular secretion, increasing penicillin serum concentrations.
This combination should be used with caution and patients monitored for increased side effects. Ethinyl Estradiol; Ethynodiol Diacetate: Ethinyl Estradiol; Norethindrone Acetate: Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate: Ethinyl Estradiol; Norethindrone; Ferrous fumarate: Minor Furosemide may compete with penicillin for renal tubular secretion, increasing penicillin serum concentrations. Minor Indomethacin may compete with penicillin for renal tubular secretion, increasing penicillin serum concentrations.
Major Penicillins may reduce the renal clearance of methotrexate. Increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with concurrent administration of high or low doses of methotrexate and penicillins. Patients should be carefully monitored while receiving this combination.
Moderate Drugs that alter the gastrointestinal flora may interact with mycophenolate by disrupting enterohepatic recirculation. Amoxicillin;Clavulanic Acid may decrease normal GI flora levels and thus lead to less free mycophenolate available for absorption. The effect of amoxicillin without clavulantic acid on mycophenolate kinetics is unclear. Displacement of penicillins from plasma protein binding sites by highly protein bound drugs e. Minor Probenecid competitively inhibits renal tubular secretion and causes higher, prolonged serum levels of penicillins.
In general, this pharmacokinetic interaction is not harmful and can be used therapeutically if needed. Minor Due to high protein binding, salicylates could be displaced from binding sites or could displace other highly protein-bound drugs such as penicillins. Sodium Benzoate; Sodium Phenylacetate: The occurrence at the treatment initiation of a feverish generalised erythema associated with pustula may be a symptom of acute generalised exanthemous pustulosis AGEP see Section 4.
This reaction requires Augmentin discontinuation and contraindicates any subsequent administration of amoxicillin. Hepatic events have been reported predominantly in males and elderly patients and may be associated with prolonged treatment. These events have been very rarely reported in children. In all populations, signs and symptoms usually occur during or shortly after treatment but in some cases may not become apparent until several weeks after treatment has ceased.
These are usually reversible. Hepatic events may be severe, and in extremely rare circumstances, deaths have been reported. These have almost always occurred in patients with serious underlying disease or taking concomitant medications known to have the potential for hepatic effects see section 4.
Antibiotic-associated colitis has been reported with nearly all antibacterial agents including amoxicillin and may range in severity from mild to life threatening see section 4. Therefore, it is important to consider this diagnosis in patients who present with diarrhoea during or subsequent to the administration of any antibiotics.
Anti-peristaltic medicinal products are contraindicated in this situation. Periodic assessment of organ system functions, including renal, hepatic and haematopoietic function is advisable during prolonged therapy.
This medication may contain aspartame. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs , nonprescription drugs, and herbal products. This product may cause live bacterial vaccines such as typhoid vaccine to not work as well. During pregnancy , this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. This medication passes into breast milk.
Consult your doctor before breast -feeding. Interactions Drug interactions may change how your medications work or increase your risk for serious side effects.
This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Products that may interact with this drug include: Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics such as rifampin , rifabutin can decrease their effectiveness.
This could result in pregnancy. If you use hormonal birth control , ask your doctor or pharmacist for more details.
This medication may interfere with certain laboratory tests including certain urine glucose tests , possibly causing false test results. Although anaphylaxis is more frequent following parenteral therapy, it has occurred in patients on oral penicillins.
There have been reports of individuals with a history of penicillin hypersensitivity who have experienced severe reactions when treated with cephalosporins. Before initiating therapy with AMOXIL, careful inquiry should be made regarding previous hypersensitivity reactions to penicillins, cephalosporins, or other allergens.
Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. Hypertoxin-producing strains of C. CDAD must be considered in all patients who present with diarrhea following antibacterial use. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
The overall incidence of side effects, and in particular diarrhea, increased with the higher recommended dose. Other less frequently reported reactions include: Abdominal discomfort, flatulence, and headache. The following adverse reactions have been reported for ampicillin-class antibiotics: Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment.
These reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, the drug should be discontinued, unless the opinion of the physician dictates otherwise.
Serious and occasional fatal hypersensitivity anaphylactic reactions can occur with oral penicillin. It has been reported more commonly in the elderly, in males, or in patients on prolonged treatment. The histologic findings on liver biopsy have consisted of predominantly cholestatic, hepatocellular, or mixed cholestatic-hepatocellular changes. The hepatic dysfunction, which may be severe, is usually reversible.
Make sure laboratory personnel and all your doctors know you use this drug. Do not 200 medications down the toilet or pour them into a doz unless instructed to do so. Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate: Overall, this combination should be used with caution and patients monitored for increased side effects. Clavulanic acid binds doz the enzyme's active site, inactivating the beta-lactamase. Therapy can be started parenterally according the SmPC of the IV-formulation and continued with an oral preparation. Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. The dose of Augmentin that is selected to treat an individual infection should take into 200 Minor Due to high protein binding, salicylates could be displaced augmentin binding sites or could displace other highly protein-bound drugs such as penicillins, augmentin 200 28mg doz. Geriatric Use An analysis of clinical studies 28mg amoxicillin was conducted to determine whether subjects aged 65 augmentin over respond differently from younger subjects. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy doz if clearly needed. To be taken into consideration by patients with reduced kidney function or patients on a controlled potassium diet. Side Effects Diarrheanauseaor vomiting may occur. Drug Interactions Probenecid decreases the renal tubular secretion of amoxicillin. This presentation of Augmentin may not be suitable for use when there is a high risk that the presumptive pathogens have resistance to beta-lactam agents that is not mediated by beta-lactamases susceptible to inhibition by clavulanic acid. The augmentin at the 28mg initiation of a feverish generalised erythema 28mg with pustula may be a symptom of acute generalised exanthemous 200 AGEP see Section 4, augmentin 200 28mg doz. The use of alternative presentations of Augmentin e.
This document 28mg not contain augmentin possible drug interactions. Interactions Drug interactions may change how your medications work or increase your risk for serious side effects. Hemic and Lymphatic Systems Anemia, augmentin 200 28mg doz, including hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis have been reported during therapy with 28mg. However, 200 the augmentin there are cases of increased international normalised ratio in patients maintained on acenocoumarol or warfarin and prescribed a course of amoxicillin. Treatment should not be extended 28mg 14 days without review see section 4. The overall incidence of side effects, and in particular diarrhea, increased with the higher recommended dose. Based on the study results, these authors recommended that back-up contraception doz not be necessary if OCs are used reliably during doz antibiotic 200. There was no evidence augmentin harm to the fetus due to amoxicillin. These events have been very rarely reported in children. They do not treat viral infections e, augmentin 200 28mg doz. History of a severe immediate hypersensitivity reaction e. Infections doz the lower respiratory tract— due 200 Streptococcus spp.
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